Reliable Detection of Mismatch Repair Deficiency in Colorectal Cancers Using Mutational Load in Next-Generation Sequencing Panels.

doi:10.1200/JCO.2015.65.1067

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Article

Reliable Detection of Mismatch Repair Deficiency in Colorectal Cancers Using Mutational Load in Next-Generation Sequencing Panels.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Jun 2016

Stadler Zsofia K, Battaglin Francesca, Middha Sumit, Hechtman Jaclyn F, Tran Christina, Cercek Andrea, Yaeger Rona, Segal Neil H, Varghese Anna M, Reidy-Lagunes Diane L, Kemeny Nancy E, Salo-Mullen Erin E, Ashraf Asad, Weiser Martin R, Garcia-Aguilar Julio, Robson Mark E, Offit Kenneth, Arcila Maria E, Berger Michael F, Shia Jinru, Solit David B, Saltz Leonard B

Abstract excerpt

PURPOSE: Tumor screening for Lynch syndrome is recommended in all or most patients with colorectal cancer (CRC). In metastatic CRC, sequencing of RAS/BRAF is necessary to guide clinical management. We hypothesized that a next-generation sequencing (NGS) panel that identifies RAS/BRAF and other actionable mutations could also reliably identify tumors with DNA mismatch repair protein deficiency (MMR-D) on the basis...

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PMID: 27022117
DOI: 10.1200/JCO.2015.65.1067
PMCID: PMC4962706

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BRAF
IMPACT
POLE

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