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Article

Genetics of clubfoot.

Journal of pediatric orthopedics. Part B - 1 Jan 2012

Dobbs Matthew B, Gurnett Christina A

Abstract excerpt

Modern advances in genetics have allowed investigators to identify the complex etiology of clubfoot. It has become increasingly apparent that clubfoot is a heterogeneous disorder with a polygenetic threshold model explaining its inheritance patterns. Several recent genetic studies have identified a key developmental pathway, the PITX1-TBX4 transcriptional pathway, as being important in clubfoot etiology. Both...

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Topics

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Share to Clubfoot
Share to Disease Models, Animal
Share to Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Multifactorial Inheritance

Share to Paired Box Transcription Factors

Share to Polymorphism, Single Nucleotide

Share to T-Box Domain Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 21817922
DOI: 10.1097/BPB.0b013e328349927c
PMCID: PMC3229717

Genes

PITX1
TBX4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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