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Article

Autophagy gene FIP200 in neural progenitors non-cell autonomously controls differentiation by regulating microglia.

The Journal of cell biology - 7 Aug 2017

Wang Chenran, Yeo Syn, Haas Michael A, Guan Jun-Lin

Abstract excerpt

Recent studies have shown important roles for autophagy genes in the regulation of different tissue stem cells, including neural stem/progenitor cells (NSCs). However, little is known about whether autophagy can regulate NSCs through cell-extrinsic mechanisms. Here, we show that deletion of an essential autophagy gene, FIP200, in NSCs increased expression of Ccl5 and Cxcl10 in a p53-independent manner, mediating...

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Identifiers

PMID: 28634261
DOI: 10.1083/jcb.201609093
PMCID: PMC5551701

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