Environment-induced epigenetic reprogramming in genomic regulatory elements in smoking mothers and their children.

doi:10.15252/msb.20156520

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Article

Environment-induced epigenetic reprogramming in genomic regulatory elements in smoking mothers and their children.

Molecular systems biology - 24 Mar 2016

Bauer Tobias, Trump Saskia, Ishaque Naveed, Thürmann Loreen, Gu Lei, Bauer Mario, Bieg Matthias, Gu Zuguang, Weichenhan Dieter, Mallm Jan-Philipp, Röder Stefan, Herberth Gunda, Takada Eiko, Mücke Oliver, Winter Marcus, Junge Kristin M, Grützmann Konrad, Rolle-Kampczyk Ulrike, Wang Qi, Lawerenz Christian, Borte Michael, Polte Tobias, Schlesner Matthias, Schanne Michaela, Wiemann Stefan, Geörg Christina, Stunnenberg Hendrik G, Plass Christoph, Rippe Karsten, Mizuguchi Junichiro, Herrmann Carl, Eils Roland, Lehmann Irina

Abstract excerpt

Epigenetic mechanisms have emerged as links between prenatal environmental exposure and disease risk later in life. Here, we studied epigenetic changes associated with maternal smoking at base pair resolution by mapping DNA methylation, histone modifications, and transcription in expectant mothers and their newborn children. We found extensive global differential methylation and carefully evaluated these changes...

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Identifiers

PMID: 27013061
DOI: 10.15252/msb.20156520
PMCID: PMC4812527

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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