Article
High-Fat Diet-Induced Obesity Enhances Allograft Rejection.
Transplantation - 1 May 2016
Molinero Luciana L, Yin Dengping, Lei Yuk Man, Chen Luqiu, Wang Ying, Chong Anita S, Alegre Maria-Luisa
Abstract excerpt
BACKGROUND: Obesity promotes a state of low-grade inflammation that exacerbates chronic inflammatory diseases, such as asthma and inflammatory bowel disease. In transplantation, the survival of organs transplanted into obese patients is reduced compared with allografts in lean recipients. However, whether this is due to increased alloimmunity remains to be addressed conclusively. METHODS: We used a mouse model of...
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