Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic mutation analysis at early stages of cell line development using next generation sequencing.

Biotechnology progress - 1 May 2016

Wright Chapman, Groot Joost, Swahn Samantha, McLaughlin Helen, Liu Mei, Xu Chongfeng, Sun Chao, Zheng Eric, Estes Scott

Abstract excerpt

A central goal for most biopharmaceutical companies is to reduce the development timeline to reach clinical proof of concept. This objective requires the development of tools that ensure the quality of biotherapeutic material destined for the clinic. Recent advances in high throughput protein analytics provide confidence in our ability to assess productivity and product quality attributes at early stages of cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cells, Cultured
Share to CHO Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Computational Biology

Share to Cricetulus

Share to High-Throughput Nucleotide Sequencing

Share to Mass Spectrometry

Share to Mutation

Share to Sequence Analysis, DNA

Source

Identifiers

PMID: 27004436
DOI: 10.1002/btpr.2263

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Genetic mutation analysis at early stages of cell line development using next generation sequencing.PMID 27004436Read ↗

Identifying low-level sequence variants via next generation sequencing to aid stable CHO cell line screening.Semantic proximity Read ↗

Benchmarking and optimization of a high-throughput sequencing based method for transgene sequence variant analysis in biotherapeutic cell line development.Semantic proximity Read ↗

Early identification of unusually clustered mutations and root causes in therapeutic antibody development.Semantic proximity Read ↗

Mutation Detection in an Antibody-Producing Chinese Hamster Ovary Cell Line by Targeted RNA Sequencing.Semantic proximity Read ↗

From mutation identification to therapy: discovery and origins of the first approved gene therapy in the Western world.Semantic proximity Read ↗

A sensitive mutation screening method supporting cell line development for biotherapeutics.Semantic proximity Read ↗

Toward theragnostics.Semantic proximity Read ↗

Barcode sequencing for understanding drug-gene interactions.Semantic proximity Read ↗

Mass spectrometry-based multi-attribute method for mutation analysis in the early development of therapeutic proteins.Semantic proximity Read ↗

Codon-Directed Determination of the Biological Causes of Sequence Variants in Therapeutic Proteins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.