Article
Glutathione S Transferases Polymorphisms Are Independent Prognostic Factors in Lupus Nephritis Treated with Cyclophosphamide.
PloS one - 1 Jan 2016
Audemard-Verger Alexandra, Martin Silva Nicolas, Verstuyft Céline, Costedoat-Chalumeau Nathalie, Hummel Aurélie, Le Guern Véronique, Sacré Karim, Meyer Olivier, Daugas Eric, Goujard Cécile, Sultan Audrey, Lobbedez Thierry, Galicier Lionel, Pourrat Jacques, Le Hello Claire, Godin Michel, Morello Rémy, Lambert Marc, Hachulla Eric, Vanhille Philippe, Queffeulou Guillaume, Potier Jacky, Dion Jean-Jacques, Bataille Pierre, Chauveau Dominique, Moulis Guillaume, Farge-Bancel Dominique, Duhaut Pierre, Saint-Marcoux Bernadette, Deroux Alban, Manuzak Jennifer, Francès Camille, Aumaitre Olivier, Bezanahary Holy, Becquemont Laurent, Bienvenu Boris
Abstract excerpt
OBJECTIVE: To investigate association between genetic polymorphisms of GST, CYP and renal outcome or occurrence of adverse drug reactions (ADRs) in lupus nephritis (LN) treated with cyclophosphamide (CYC). CYC, as a pro-drug, requires bioactivation through multiple hepatic cytochrome P450s and glutathione S transferases (GST). METHODS: We carried out a multicentric retrospective study including 70 patients with...
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