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Article

Epistatic interactions among CYP2C19*2, CYP3A4 and GSTP1 on the cyclophosphamide therapy in lupus nephritis patients.

Pharmacogenomics - 1 Oct 2017

Kumaraswami Konda, Katkam Shiva Krishna, Aggarwal Amita, Sharma Aman, Manthri Ramesh, Kutala Vijay Kumar, Rajasekhar Liza

Abstract excerpt

AIM: To investigate the impact of genetic variants in CYP2C9, CYP2C19, CYP3A4, GSTT1, GSTM1 and GSTP1 on the efficacy of cyclophosphamide (CYC) therapy in patients with lupus nephritis. MATERIALS & METHODS: Lupus nephritis patients (n = 220) treated with CYC were included in the study. RESULTS: Logistic regression analysis identified CYP2C19*2 as an independent predictor of CYC therapeutic failure (odds ratio...

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Share to Cyclophosphamide
Share to Cytochrome P-450 CYP2C19

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP3A

Share to GSTP1 gene

Share to Glutathione S-Transferase pi

Share to Lupus Nephritis

Share to Polymorphism, Single Nucleotide

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Source

Identifiers

PMID: 28976264
DOI: 10.2217/pgs-2017-0069

Genes

GSTP1
GSTM1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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