Article
New KEL*01M and KEL*02M alleles: structural modeling to assess the impact of amino acid changes.
Transfusion - 1 May 2016
Silvy Monique, Callebaut Isabelle, Filosa Lugdivine, Granier Thomas, Chiaroni Jacques, Bailly Pascal
Abstract excerpt
BACKGROUND: The KELL antigens are carried by the well-folded and highly polymorphic glycoprotein KELL, belonging to the M13 family of metalloproteases. Anti-KEL, particularly anti-KEL1, are clinically significant. We retrospectively investigated genomic DNA from samples with uncertain KEL1 or KEL2 phenotype and identified six novel Kmod alleles. We then considered a model of the protein three-dimensional (3D)...
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