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Article

A structure-based in silico analysis of the Kell blood group system.

Frontiers in immunology - 1 Jan 2024

Mayr Gabriele, Bublitz Maike, Steiert Tim A, Löscher Britt-Sabina, Wittig Michael, ElAbd Hesham, Gassner Christoph, Franke Andre

Abstract excerpt

Kell is one of the most complex blood group systems, with a highly polymorphic genetic background. Extensive allelic variations in the KEL gene affect the encoded erythrocyte surface protein Kell. Genetic variants causing aberrant splicing, premature termination of protein translation, or specific amino acid exchanges lead to a variety of different phenotypes with altered Kell expression levels or changes in the...

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Identifiers

PMID: 39726599
DOI: 10.3389/fimmu.2024.1452637
PMCID: PMC11669894

Genes

KEL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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