Article
The Kell protein of the common K2 phenotype is a catalytically active metalloprotease, whereas the rare Kell K1 antigen is inactive. Identification of novel substrates for the Kell protein.
The Journal of biological chemistry - 3 Jun 2005
Clapéron Audrey, Rose Christiane, Gane Pierre, Collec Emmanuel, Bertrand Olivier, Ouimet Tanja
Abstract excerpt
The Kell blood group is a highly polymorphic system containing over 20 different antigens borne by the protein Kell, a 93-kDa type II glycoprotein that displays high sequence homology with members of the M13 family of zinc-dependent metalloproteases whose prototypical member is neprilysin. Kell K1 is an antigen expressed in 9% of the Caucasian population, characterized by a point mutation (T193M) of the Kell K2...
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