cDNA sequencing reveals an unexpected splice variation leading to weak KEL2 expression.

Abstract excerpt

BACKGROUND: KEL1 antigen expression is routinely tested in blood donors in Switzerland. A donor sample with an apparent rare KEL:1,-2 phenotype was genotyped KEL*01.01/KEL*02. A series of detailed molecular analyses were performed to solve this discrepancy, and a novel variant KEL*02 allele was identified. MATERIALS AND METHODS: Standard serological column agglutination and in-house adsorption-elution testing...

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