Article
Gia/Mthl5 is an aorta specific GPCR required for Drosophila heart tube morphology and normal pericardial cell positioning.
Developmental biology - 1 Jun 2016
Patel Meghna V, Zhu Jun-Yi, Jiang Zhiping, Richman Adam, VanBerkum Mark F A, Han Zhe
Abstract excerpt
G-protein signaling is known to be required for cell-cell contacts during the development of the Drosophila dorsal vessel. However, the identity of the G protein-coupled receptor (GPCR) that regulates this signaling pathway activity is unknown. Here we describe the identification of a novel cardiac specific GPCR, called Gia, for "GPCR in aorta". Gia is the only heart-specific GPCR identified in Drosophila to date...
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