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Article

Epithelial Junction Opener Improves Oncolytic Adenovirus Therapy in Mouse Tumor Models.

Human gene therapy - 1 Apr 2016

Yumul Roma, Richter Maximilian, Lu Zhuo-Zhuang, Saydaminova Kamola, Wang Hongjie, Wang Chung-Huei Katherine, Carter Darrick, Lieber André

Abstract excerpt

A central resistance mechanism in solid tumors is the maintenance of epithelial junctions between malignant cells that prevent drug penetration into the tumor. Human adenoviruses (Ads) have evolved mechanisms to breach epithelial barriers. For example, during Ad serotype 3 (Ad3) infection of epithelial tumor cells, massive amounts of subviral penton-dodecahedral particles (PtDd) are produced and released from...

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Share to Adenoviridae
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial Cells

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Source

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Identifiers

PMID: 26993072
DOI: 10.1089/hum.2016.022
PMCID: PMC4840918

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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