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Article

Development of a versatile oncolytic virus platform for local intra-tumoural expression of therapeutic transgenes

18 May 2017

Abstract excerpt

Oncolytic viruses which infect and kill tumour cells can also be genetically modified to express therapeutic genes that augment their anti-cancer activities. Modifying oncolytic viruses to produce effective cancer therapies is challenging as encoding transgenes often attenuates virus activity or prevents systemic delivery in patients due to the risk of off-target expression of transgenes in healthy tissues. To...

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PMID: 28542292
DOI: 10.1371/journal.pone.0177810

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