Article
Polymorphisms of Selected DNA Repair Genes and Lung Cancer in Chromium Exposure.
Advances in experimental medicine and biology - 1 Jan 2016
Halasova E, Matakova T, Skerenova M, Krutakova M, Slovakova P, Dzian A, Javorkova S, Pec M, Kypusova K, Hamzik J
Abstract excerpt
Chromium is a well-known mutagen and carcinogen involved in lung cancer development. DNA repair genes play an important role in the elimination of genetic changes caused by chromium exposure. In the present study, we investigated the polymorphisms of the following DNA repair genes: XRCC3, participating in the homologous recombination repair, and hMLH1 and hMSH2, functioning in the mismatch repair. We focused on...
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