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Article

Novel indolyl-chalcones target stathmin to induce cancer cell death

17 Mar 2016

Abstract excerpt

Efficacy of current therapies for advanced and metastatic cancers remains a challenge in clinical practice. We investigated the anti-cancer potency of 3 novel indoly-chalcones (CITs). Our results indicated the lead molecule CIT-026 (Formula = C20H16FNO) induced cell death in prostate and lung cancer cell lines at sub-micromolar concentration. CITs (CIT-026, CIT-214, CIT-223) lead to microtubule destabilization,...

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PMID: 26986925
DOI: 10.1080/15384101.2016.1160980

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