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Natural and Semisynthetic Chalcones as Dual FLT3 and Microtubule Polymerization Inhibitors

25 Sept 2020

Abstract excerpt

Activating mutations in FLT3 receptor tyrosine kinase are found in a third of acute myeloid leukemia (AML) patients and are associated with disease relapse and a poor prognosis. The majority of these mutations are internal tandem duplications (ITDs) in the juxtamembrane domain of FLT3, which have been validated as a therapeutic target. The clinical success of selective inhibitors targeting oncogenic FLT3,...

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PMID: 32975953
DOI: 10.1021/acs.jnatprod.0c00699

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