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Autophagy Plays a Protective Role in Tumor Necrosis Factor-α-Induced Apoptosis of Bone Marrow-Derived Mesenchymal Stem Cells.

Stem cells and development - 15 May 2016

Yang Rui, Ouyang Yi, Li Weiping, Wang Peng, Deng Haiquan, Song Bin, Hou Jingyi, Chen Zhong, Xie Zhongyu, Liu Zhenhua, Li Jinteng, Cen Shuizhong, Wu Yanfeng, Shen Huiyong

Abstract excerpt

Bone marrow-derived mesenchymal stem cells (BMSCs) are being broadly investigated for treating numerous inflammatory diseases. However, the low survival rate of BMSCs during the transplantation process has limited their application. Autophagy can maintain cellular homeostasis and protect cells against environmental stresses. Tumor necrosis factor-α (TNF-α) is an important inflammatory cytokine that can induce...

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PMID: 26985709
DOI: 10.1089/scd.2015.0387

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BECN1

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