Article
Short-Term Autophagy Preconditioning Upregulates the Expression of COX2 and PGE2 and Alters the Immune Phenotype of Human Adipose-Derived Stem Cells In Vitro.
Cells - 19 Apr 2022
Wise Rachel M, Al-Ghadban Sara, Harrison Mark A A, Sullivan Brianne N, Monaco Emily R, Aleman Sarah J, Donato Umberto M, Bunnell Bruce A
Abstract excerpt
Human adipose-derived stem cells (hASCs) are potent modulators of inflammation and promising candidates for the treatment of inflammatory and autoimmune diseases. Strategies to improve hASC survival and immunoregulation are active areas of investigation. Autophagy, a homeostatic and stress-induced degradative pathway, plays a crucial role in hASC paracrine signaling-a primary mechanism of therapeutic action....
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