Article
Joint effects of diabetic-related genomic loci on the therapeutic efficacy of oral anti-diabetic drugs in Chinese type 2 diabetes patients.
Scientific reports - 17 Mar 2016
Chen Miao, Zhang Rong, Jiang Feng, Wang Jie, Peng Danfeng, Yan Jing, Wang Shiyun, Wang Tao, Bao Yuqian, Hu Cheng, Jia Weiping
Abstract excerpt
Previous pharmacogenomic studies of oral anti-diabetic drugs have primarily focused on the effect of a single site. This study aimed to examine the joint effects of multiple loci on repaglinide or rosiglitazone efficacy in newly diagnosed type 2 diabetes mellitus (T2DM) patients. A total of 209 newly diagnosed T2DM patients were randomly assigned to treatment with repaglinide or rosiglitazone for 48 weeks. The...
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