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Article

Tetraspanin 6 is a regulator of carcinogenesis in colorectal cancer

14 Sept 2021

Abstract excerpt

mice, a well-established model for premalignant CRC, resulted in increased incidence of adenoma formation and tumor size. We demonstrate that the effect of Tspan6 deletion results in the activation of EGF-dependent signaling pathways through increased production of the transmembrane form of TGF-α (tmTGF-α) associated with extracellular vesicles. This pathway is modulated by an adaptor protein syntenin-1, which...

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PMID: 34521767
DOI: 10.1073/pnas.2011411118

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