Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evaluation of effects of indoxyl sulfate and parathyroid hormone on CYP3A activity considering the influence of CYP3A5 gene polymorphisms.

British journal of clinical pharmacology - 1 Dec 2023

Oda Ayako, Suzuki Yosuke, Yoshijima Chisato, Sato Haruki, Tanaka Ryota, Ono Hiroyuki, Tatsuta Ryosuke, Ando Tadasuke, Shin Toshitaka, Itoh Hiroki, Ohno Keiko

Abstract excerpt

AIMS: Indoxyl sulfate and parathyroid hormone (PTH), which accumulate in chronic kidney disease (CKD), have been reported to reduce cytochrome P450(CYP)3A activity. Homozygotes of the CYP3A5*3 allele have reduced CYP3A5 activity compared to carriers of at least one CYP3A5*1 allele. 4β-Hydroxycholesterol (4β-OHC) has been established as an endogenous substrate reflecting CYP3A activity. 4β-OHC is produced through...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cholesterol
Share to Cytochrome P-450 CYP3A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

Share to Hydroxycholesterols

Share to Parathyroid Hormone

Share to Polymorphism, Genetic

Share to Renal Insufficiency, Chronic

Source

Identifiers

PMID: 37522799
DOI: 10.1111/bcp.15866

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Evaluation of effects of indoxyl sulfate and parathyroid hormone on CYP3A activity considering the influence of CYP3A5 gene polymorphisms.PMID 37522799Read ↗

Association of plasma concentration of 4β-hydroxycholesterol with CYP3A5 polymorphism and plasma concentration of indoxyl sulfate in stable kidney transplant recipients.Semantic proximity Read ↗

The Effects of CKD on Cytochrome P450-Mediated Drug Metabolism.Semantic proximity Read ↗

Drug-metabolizing enzymes CYP3A as a link between tacrolimus and vitamin D in renal transplant recipients: is it relevant in clinical practice?Semantic proximity Read ↗

Retention of indoxyl sulfate in different genotypes of ABCC2 may explain variation in tacrolimus pharmacokinetics.Semantic proximity Read ↗

The Impact of Uremia and Intestinal Dysbiosis on Hepatic Drug Metabolism in a Rat Model of Progressive Chronic Kidney DiseaseSemantic proximity Read ↗

Association of CYP3A5 polymorphisms and parathyroid hormone with blood level of tacrolimus in patients with end-stage renal disease.Semantic proximity Read ↗

4β-Hydroxycholesterol, an endogenous marker of CYP3A4/5 activity in humans.Semantic proximity Read ↗

Phylloquinone transport and its influence on gamma-carboxyglutamate residues of osteocalcin in patients on maintenance hemodialysis.Semantic proximity Read ↗

Impact of CYP3A5 genotype on tolvaptan pharmacokinetics and their relationships with endogenous markers of CYP3A activity and serum sodium level in heart failure patients.Semantic proximity Read ↗

Interaction between two sulfate-conjugated uremic toxins, p-cresyl sulfate and indoxyl sulfate, during binding with human serum albumin.Semantic proximity Read ↗

Characterization of hepatic cytochrome p4503A activity in patients with end-stage renal disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.