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ECL1i, d(LGTFLKC), a novel, small peptide that specifically inhibits CCL2‐dependent migration

15 Mar 2016

Abstract excerpt

CC chemokine receptor type 2 (CCR2) is a key molecule in inflammatory diseases and is an obvious drug target for the treatment of inflammation. A number of nonpeptidic, competitive CCR2 antagonists have been developed, but none has yet been approved for clinical use. Our aim was to identify a short peptide that showed allosteric antagonism against human and mouse CCR2. On the basis of sequence analysis and...

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PMID: 26979087
DOI: 10.1096/fj.201500116

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