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Article

High-fat diet disrupts metabolism in two generations of rats in a parent-of-origin specific manner

23 Aug 2016

Abstract excerpt

Experimental and epidemiological evidence demonstrate that ancestral diet might contribute towards offspring health. This suggests that nutrition may be able to modify genetic or epigenetic information carried by germ cells (GCs). To examine if a parental high fat diet (HFD) influences metabolic health in two generations of offspring, GC-eGFP Sprague Dawley rats were weaned onto HFD (45% fat) or Control Diet (CD;...

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PMID: 27550193
DOI: 10.1038/srep31857

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