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Article

A Mutation in IL4RA Is Associated with the Degree of Pathology in Human TB Patients.

Mediators of inflammation - 1 Jan 2016

Hölscher Christoph, Heitmann Lisa, Owusu-Dabo Ellis, Horstmann Rolf D, Meyer Christian G, Ehlers Stefan, Thye Thorsten

Abstract excerpt

The contribution of interleukin- (IL-) 4 receptor-alpha- (Rα-) dependent events in the pathogenesis of tuberculosis (TB) is controversial. We have recently shown IL-13 overexpression in mice to cause recrudescent Mtb replication and centrally necrotizing granulomas strongly resembling pathology of human TB. A deletion of IL-4Rα completely abrogates TB tissue pathology in these mice. To validate our results in...

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Identifiers

PMID: 26977119
DOI: 10.1155/2016/4245028
PMCID: PMC4764744

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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