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Article

Impaired 17,20-Lyase Activity in Male Mice Lacking Cytochrome b5 in Leydig Cells.

Molecular endocrinology (Baltimore, Md.) - 1 Apr 2016

Sondhi Varun, Owen Bryn M, Liu Jiayan, Chomic Robert, Kliewer Steven A, Hughes Beverly A, Arlt Wiebke, Mangelsdorf David J, Auchus Richard J

Abstract excerpt

Androgen and estrogen biosynthesis in mammals requires the 17,20-lyase activity of cytochrome P450 17A1 (steroid 17-hydroxylase/17,20-lyase). Maximal 17,20-lyase activity in vitro requires the presence of cytochrome b5 (b5), and rare cases of b5 deficiency in human beings causes isolated 17,20-lyase deficiency. To study the consequences of conditional b5 removal from testicular Leydig cells in an animal model, we...

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Identifiers

PMID: 26974035
DOI: 10.1210/me.2015-1282
PMCID: PMC4814474

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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