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Article

KCNQ1 gene variants in the risk for type 2 diabetes and impaired renal function in the Spanish Renastur cohort.

Molecular and cellular endocrinology - 15 May 2016

Riobello Cristina, Gómez Juan, Gil-Peña Helena, Tranche Salvador, Reguero Julián R, de la Hera Jesús M, Delgado Elías, Calvo David, Morís César, Santos Fernando, Coto-Segura Pablo, Iglesias Sara, Alonso Belén, Alvarez Victoria, Coto Eliecer

Abstract excerpt

Several common KCNQ1 gene polymorphisms have been associated with the risk of type 2 diabetes (T2DM) and diabetic nephropathy. This effect is explained by the role of the kcnq1 protein as a potassium channel that in the pancreatic beta-cells drives an electrical signal that facilitates glucose-stimulated insulin secretion. The KCNQ1 gene is also expressed in the kidney, and could thus be implicated in the risk of...

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Identifiers

PMID: 26970180
DOI: 10.1016/j.mce.2016.03.007

Genes

KCNQ1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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