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Article

Resolvin D1 reduces inflammation in co-cultures of primary human macrophages and adipocytes by triggering macrophages.

Prostaglandins, leukotrienes, and essential fatty acids - 1 Nov 2021

Gemperle Claudio, Tran Syndi, Schmid Mattia, Rimann Nicole, Marti-Jaun Jacqueline, Hartling Ivan, Wawrzyniak Paulina, Hersberger Martin

Abstract excerpt

Obesity leads to chronic inflammation of the adipose tissue which is tightly associated with the metabolic syndrome, type 2 diabetes and cardiovascular disease. Inflammation of the adipose tissue is mainly characterized by the presence of crown-like structures composed of inflammatory macrophages in the neighborhood of adipocytes. Resolvin D1 (RvD1), a potent anti-inflammatory and pro-resolving lipid mediator...

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Identifiers

PMID: 34740032
DOI: 10.1016/j.plefa.2021.102363

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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