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Article

The Uromodulin Gene Locus Shows Evidence of Pathogen Adaptation through Human Evolution.

Journal of the American Society of Nephrology : JASN - 1 Oct 2016

Ghirotto Silvia, Tassi Francesca, Barbujani Guido, Pattini Linda, Hayward Caroline, Vollenweider Peter, Bochud Murielle, Rampoldi Luca, Devuyst Olivier

Abstract excerpt

Common variants in the UMOD gene encoding uromodulin, associated with risk of hypertension and CKD in the general population, increase UMOD expression and urinary excretion of uromodulin, causing salt-sensitive hypertension and renal lesions. To determine the effect of selective pressure on variant frequency, we investigated the allelic frequency of the lead UMOD variant rs4293393 in 156 human populations, in...

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Source

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Identifiers

PMID: 26966016
DOI: 10.1681/ASN.2015070830
PMCID: PMC5042664

Genes

UMOD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Uromodulin Gene Locus Shows Evidence of Pathogen Adaptation through Human Evolution.PMID 26966016Read ↗

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Uromodulin as a protein and genetic biomarker for hypertension: a detailed systematic review & meta-analysisSemantic proximity Read ↗

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