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Article

SIV Infection-Mediated Changes in Gastrointestinal Bacterial Microbiome and Virome Are Associated with Immunodeficiency and Prevented by Vaccination.

Cell host & microbe - 9 Mar 2016

Handley Scott A, Desai Chandni, Zhao Guoyan, Droit Lindsay, Monaco Cynthia L, Schroeder Andrew C, Nkolola Joseph P, Norman Megan E, Miller Andrew D, Wang David, Barouch Dan H, Virgin Herbert W

Abstract excerpt

AIDS caused by simian immunodeficiency virus (SIV) infection is associated with gastrointestinal disease, systemic immune activation, and, in cross-sectional studies, changes in the enteric virome. Here we performed a longitudinal study of a vaccine cohort to define the natural history of changes in the fecal metagenome in SIV-infected monkeys. Matched rhesus macaques were either uninfected or intrarectally...

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Source

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Identifiers

PMID: 26962943
DOI: 10.1016/j.chom.2016.02.010
PMCID: PMC4802495

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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