Article
Body composition of the host influences dendritic cell phenotype in patients treated for colorectal cancer.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Aug 2016
Malietzis George, Lee Gui Han, Al-Hassi Hafid O, Bernardo David, Blakemore Alexandra I F, Kennedy Robin H, Moorghen Morgan, Jenkins John T, Knight Stella C
Abstract excerpt
Dendritic cells (DCs) are antigen-presenting cells that can acquire tumour antigens and initiate cytotoxic T cell reactions. Obesity has been proposed as a cause for tumours escaping immune surveillance, but few studies investigate the impact of other body composition parameters. We examined the relationship of DC phenotype with computer tomography (CT)-defined parameters in patients with colorectal cancer (CRC)....
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