Back to search

Article

Body composition predicts poor outcomes and reveals immunometabolic dysfunction via single-cell profiling in anti-BCMA CAR T-treated myeloma

2025-08-28

Abstract excerpt

Chimeric Antigen Receptor (CAR) T-cell therapy has transformed the treatment of relapsed or refractory multiple myeloma (RRMM), yet outcomes remain heterogenous. The prognostic role of body composition in this context is unknown. We retrospectively analyzed 108 RRMM patients treated with anti-B-cell maturation antigen (BCMA) CAR T-cell therapy. Pre-treatment Computed tomography imaging was utilized to quantify tot...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
ef3e3688-0f02-5543-aa97-506ad3bc238b
DOI
10.1101/2025.08.23.25334251
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Body composition predicts poor outcomes and reveals immunometabolic dysfunction via single-cell profiling in anti-BCMA CAR T-treated myelomaDOI 10.1101/2025.08.23.25334251
Association of computed tomography scan–assessed body composition with immune and PI3K/AKT pathway proteins in distinct breast cancer tumor componentsSemantic proximity
Obesity, Sarcopenia, and Outcomes in Non-Small Cell Lung Cancer Patients Treated With Immune Checkpoint Inhibitors and Tyrosine Kinase InhibitorsSemantic proximity
Conventional Treatment for Multiple Myeloma Drives Premature Aging Phenotypes and Metabolic Dysfunction in T Cells.Semantic proximity
Body composition measures as a determinant of Alpelisib related toxicitySemantic proximity
Body composition measures as a determinant of Alpelisib related toxicity.Semantic proximity
Clinically relevant body composition phenotypes are associated with distinct circulating cytokine and metabolomic milieus in epithelial ovarian cancer patients.Semantic proximity
CD8 + T cell metabolism and function are suppressed by long-chain fatty acid uptake from the bone marrow microenvironment in Multiple MyelomaSemantic proximity
Myeloma-Modified Adipocytes Exhibit Metabolic Dysfunction and a Senescence-Associated Secretory Phenotype.Semantic proximity
A plasma proteomic signature of cancer-related sarcopenia implicates the IGFBP axis in muscle dysfunctionSemantic proximity
Impact of body composition and muscle health phenotypes on survival outcomes in colorectal cancer: a multicenter cohort.Semantic proximity
Sex-specific Body Composition Features Impacting Survival Outcomes in Surgically Managed Clear Cell Renal Cell CarcinomaSemantic proximity
The association of body composition phenotypes before chemotherapy with epithelial ovarian cancer mortality.Semantic proximity
Select a neighboring publication to make it the new centre.