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Article

Dendritic cell populations with different concentrations of lipid regulate tolerance and immunity in mouse and human liver.

Gastroenterology - 1 Oct 2012

Ibrahim Junaid, Nguyen Andrew H, Rehman Adeel, Ochi Atsuo, Jamal Mohsin, Graffeo Christopher S, Henning Justin R, Zambirinis Constantinos P, Fallon Nina C, Barilla Rocky, Badar Sana, Mitchell Aaron, Rao Raghavendra S, Acehan Devrim, Frey Alan B, Miller George

Abstract excerpt

BACKGROUND & AIMS: Immune cells of the liver must be able to recognize and react to pathogens yet remain tolerant to food molecules and other nonpathogens. Dendritic cells (DCs) are believed to contribute to hepatic tolerance. Lipids have been implicated in dysfunction of DCs in cancer. Therefore, we investigated whether high lipid content in liver DCs affects induction of tolerance. METHODS: Mouse and human...

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Identifiers

PMID: 22705178
DOI: 10.1053/j.gastro.2012.06.003
PMCID: PMC3459067

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