Article
Visceral fat adipocytes from obese and colorectal cancer subjects exhibit distinct secretory and ω6 polyunsaturated fatty acid profiles and deliver immunosuppressive signals to innate immunity cells.
Oncotarget - 27 Sept 2016
Del Cornò Manuela, D'Archivio Massimo, Conti Lucia, Scazzocchio Beatrice, Varì Rosaria, Donninelli Gloria, Varano Barbara, Giammarioli Stefania, De Meo Simone, Silecchia Gianfranco, Pennestrì Francesco, Persiani Roberto, Masella Roberta, Gessani Sandra
Abstract excerpt
Obesity is a low-grade chronic inflammatory state representing an important risk factor for colorectal cancer (CRC). Adipocytes strongly contribute to inflammation by producing inflammatory mediators. In this study we investigated the role of human visceral fat adipocytes in regulating the functions of innate immunity cells. Adipocyte-conditioned media (ACM) from obese (n = 14) and CRC (lean, n = 14; obese, n =...
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