Article
Evolutionary diversification of the BetaM interactome acquired through co-option of the ATP1B4 gene in placental mammals.
Scientific reports - 4 Mar 2016
Korneenko Tatyana V, Pestov Nikolay B, Ahmad Nisar, Okkelman Irina A, Dmitriev Ruslan I, Shakhparonov Mikhail I, Modyanov Nikolai N
Abstract excerpt
ATP1B4 genes represent a rare instance of orthologous vertebrate gene co-option that radically changed properties of the encoded BetaM proteins, which function as Na,K-ATPase subunits in lower vertebrates and birds. Eutherian BetaM has lost its ancestral function and became a muscle-specific resident of the inner nuclear membrane. Our earlier work implicated BetaM in regulation of gene expression through direct...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.