Article

MBNL1 Regulates the Expression and Alternative Splicing of Genes Enriched in Cell Adhesion and Apoptosis

2021-07-29

Abstract excerpt

Muscleblind Like Splicing Regulator 1 (MBNL1), one canonical RNA binding protein (RBP), plays important roles in the regulation of the alternative splicing (AS) on pre-mRNAs. MBNL1 has traditionally been considered involved in the pathogenesis of myotonic dystrophy. Recent researches point out that MBNL1 has an effect on cancer progress, but the underlying mechanisms are unclear. In this study, we obtained the reg...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1f96eb22-7081-516b-b1e6-4a13e291ed9e
DOI: 10.21203/rs.3.rs-731723/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MBNL1 Regulates the Expression and Alternative Splicing of Genes Enriched in Cell Adhesion and ApoptosisDOI 10.21203/rs.3.rs-731723/v1Read

Alternative splicing regulation by Muscleblind proteins: from development to diseaseSemantic proximity Read

Autoregulated Splicing of muscleblind-like 1 (MBNL1) Pre-mRNASemantic proximity Read

A known expressed sequence tag, BM742401, is a potent lincRNA inhibiting cancer metastasis.Semantic proximity Read

An Overview of Alternative Splicing Defects Implicated in Myotonic Dystrophy Type ISemantic proximity Read

Large-scale analysis of genome and transcriptome alterations in multiple tumors unveils novel cancer-relevant splicing networksSemantic proximity Read

Characterization of LIMA1 and its emerging roles and potential therapeutic prospects in cancersSemantic proximity Read

The transcriptional repressor BCL11A promotes breast cancer metastasisSemantic proximity Read

Commitment to Myogenic Differentiation Significantly Aggravates the RNA Phenotype in Myotonic Dystrophy Type 1.Semantic proximity Read

Large-scale analysis of genome and transcriptome alterations in multiple tumors unveils novel cancer-relevant splicing networks.Semantic proximity Read

Muscle-Specific Mis-Splicing and Heart Disease Exemplified by RBM20Semantic proximity Read

UNC5B-AS1 promotes the proliferation, migration and EMT of hepatocellular carcinoma cells via regulating miR-4306/KDM2A axisSemantic proximity Read

Interconnection between molecular regulators in LMNA related muscular dystrophySemantic proximity Read