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Article

Primary Ovarian Insufficiency Induced by Fanconi Anemia E Mutation in a Mouse Model.

PloS one - 1 Jan 2016

Fu Chun, Begum Khurshida, Overbeek Paul A

Abstract excerpt

In most cases of primary ovarian insufficiency (POI), the cause of the depletion of ovarian follicles is unknown. Fanconi anemia (FA) proteins are known to play important roles in follicular development. Using random insertional mutagenesis with a lentiviral transgene, we identified a family with reduced fertility in the homozygous transgenic mice. We identified the integration site and found that the lentivirus...

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Identifiers

PMID: 26939056
DOI: 10.1371/journal.pone.0144285
PMCID: PMC4777492

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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