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Article

Influence of the polymorphism of the DUSP14 gene on the expression of immune-related genes and development of pulmonary tuberculosis.

Genes and immunity - 1 Jun 2016

Hijikata M, Matsushita I, Le Hang N T, Thuong P H, Tam D B, Maeda S, Sakurada S, Cuong V C, Lien L T, Keicho N

Abstract excerpt

Recently, a genome-wide screening identified a functional single-nucleotide polymorphism in dual-specificity phosphatase 14 gene (DUSP14), which was associated with pulmonary tuberculosis (TB) in a West African study. DUSP14 regulates T-cell proliferation and cytokine production in a negative way via dephosphorylation and inactivation of key signaling molecules. The aim of this study is to further explore the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide

Share to Receptors, Interferon

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Share to STAT1 Transcription Factor

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Source

Identifiers

PMID: 26938665
DOI: 10.1038/gene.2016.11

Genes

DUSP14
IFNGR2
STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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