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Article

Pathway Analyses Identify Novel Variants in the WNT Signaling Pathway Associated with Tuberculosis in Chinese Population.

Scientific reports - 23 Jun 2016

Hu Xuejiao, Zhou Juan, Chen Xuerong, Zhou Yanhong, Song Xingbo, Cai Bei, Zhang Jingya, Lu Xiaojun, Ying Binwu

Abstract excerpt

Tuberculosis remains a global public health problem, and its immunopathogenesis is still poorly understood. In this study, 25 single nucleotide polymorphisms (SNPs) in the WNT pathway were evaluated in relation to tuberculosis risk in a Chinese Han discovery set, and 6 candidate susceptible SNPs were further validated in a Chinese Tibetan cohort. Luciferase reporter assay, RT-qPCR and Western blot were used to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27334567
DOI: 10.1038/srep28530
PMCID: PMC4917881

Genes

CTNNB1
SFRP1
CRP

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