Article
Activation of autophagy ameliorates age-related neurogenesis decline and neurodysfunction in adult mice
2021-04-08
Abstract excerpt
<title>Abstract</title> <p>Adult neurogenesis is the ongoing generation of functional new neurons from neural progenitor cells (NPCs) in the mammalian brain. However, this process declines with aging, which is implicated in the recession of brain function and neurodegeneration. Understanding the mechanism of adult neurogenesis and stimulating it will benefit the mitigation of neurodegenerative diseases. Autophagy...
Topics
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- FOXO transcription factor regulation
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Genetics, Aging, and Longevity in Model Organisms
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Pluripotent Stem Cells Research
Identifiers and source
- Literature Corpus work
- 414f1df8-221f-53d0-a7f2-813e5f737546
- DOI
- 10.21203/rs.3.rs-359844/v1
