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Targeted demethylation at the CDKN1C/p57 locus induces human β cell replication

29 Oct 2018

Abstract excerpt

The loss of insulin-secreting β cells is characteristic among type I and type II diabetes. Stimulating proliferation to expand sources of β cells for transplantation remains a challenge because adult β cells do not proliferate readily. The cell cycle inhibitor p57 has been shown to control cell division in human β cells. Expression of p57 is regulated by the DNA methylation status of the imprinting control region...

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Share to Epigenetics and DNA Methylation
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Share to Pancreatic function and diabetes

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PMID: 30352048
DOI: 10.1172/jci99170

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