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Article

Differential gene expression studies to explore the molecular pathophysiology of Down syndrome.

Brain research. Brain research reviews - 1 Oct 2001

Antonarakis S E, Lyle R, Chrast R, Scott H S

Abstract excerpt

Trisomy 21, which causes Down syndrome, is the model human disorder due to the presence of a supernumerary chromosome. The completion of the sequence of chromosome 21 and the development of appropriate animal models now provide the molecular infrastructure and the reagents to elucidate the molecular mechanisms of the different phenotypes of Down syndrome. The study of the overexpression of single genes, and the...

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Identifiers

PMID: 11690624
DOI: 10.1016/s0165-0173(01)00103-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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