Article
Hypotaurine evokes a malignant phenotype in glioma through aberrant hypoxic signaling.
Oncotarget - 22 Mar 2016
Gao Peng, Yang Chunzhang, Nesvick Cody L, Feldman Michael J, Sizdahkhani Saman, Liu Huailei, Chu Huiying, Yang Fengxu, Tang Ling, Tian Jing, Zhao Shiguang, Li Guohui, Heiss John D, Liu Yang, Zhuang Zhengping, Xu Guowang
Abstract excerpt
Metabolomics has shown significant potential in identifying small molecules specific to tumor phenotypes. In this study we analyzed resected tissue metabolites using capillary electrophoresis-mass spectrometry and found that tissue hypotaurine levels strongly and positively correlated with glioma grade. In vitro studies were conducted to show that hypotaurine activates hypoxia signaling through the competitive...
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