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Article

Acetate Supplementation as a Means of Inducing Glioblastoma Stem-Like Cell Growth Arrest

9 Jan 2015

Abstract excerpt

Glioblastoma (GBM), the most common primary adult malignant brain tumor, is associated with a poor prognosis due, in part, to tumor recurrence mediated by chemotherapy and radiation resistant glioma stem-like cells (GSCs). The metabolic and epigenetic state of GSCs differs from their non-GSC counterparts, with GSCs exhibiting greater glycolytic metabolism and global hypoacetylation. However, little attention has...

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PMID: 25573156
DOI: 10.1002/jcp.24927

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