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Article

Emergence of polymyxin B resistance influences pathogenicity in Pseudomonas aeruginosa mutators.

Antimicrobial agents and chemotherapy - 1 Jul 2015

Bulman Zackery P, Sutton Mark D, Ly Neang S, Bulitta Jurgen B, Holden Patricia N, Nation Roger L, Li Jian, Tsuji Brian T

Abstract excerpt

The interplay between polymyxin B pharmacodynamics and pathogenicity was examined in Pseudomonas aeruginosa PAO1 and isogenic DNA repair-deficient mutators (mutM and mutS strains). Against mutS mutators, polymyxin B initial killing was concentration dependent, with >99.9% bacterial reduction at 2...

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Identifiers

PMID: 25918151
DOI: 10.1128/AAC.04629-14
PMCID: PMC4468730

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25918151-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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