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WS-SNPs&GO: a web server for predicting the deleterious effect of human protein variants using functional annotation.

BMC genomics - 1 Jan 2013

Capriotti Emidio, Calabrese Remo, Fariselli Piero, Martelli Pier Luigi, Altman Russ B, Casadio Rita

Abstract excerpt

BACKGROUND: SNPs&GO is a method for the prediction of deleterious Single Amino acid Polymorphisms (SAPs) using protein functional annotation. In this work, we present the web server implementation of SNPs&GO (WS-SNPs&GO). The server is based on Support Vector Machines (SVM) and for a given protein, its input comprises: the sequence and/or its three-dimensional structure (when available), a set of target...

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Algorithms
Amino Acid Substitution
Computational Biology
Genetic Variation
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Molecular Sequence Annotation

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PMID: 23819482
DOI: 10.1186/1471-2164-14-S3-S6
PMCID: PMC3665478

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