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The Brucella melitensis M5-90 phosphoglucomutase (PGM) mutant is attenuated and confers protection against wild-type challenge in BALB/c mice.

World journal of microbiology & biotechnology - 1 Apr 2016

Zhang Yu, Li Tiansen, Zhang Jing, Li Zhiqiang, Zhang Yan, Wang Zhen, Feng Hanping, Wang Yuanzhi, Chen Chuangfu, Zhang Hui

Abstract excerpt

Brucellae are Gram-negative intracellular bacterial pathogens that infect humans and animals, bringing great economic burdens to developing countries. Live attenuated Brucella vaccines (strain M5-90 or others) are the most efficient means for prevention and control of animal brucellosis. However, these vaccines have several drawbacks, including residual virulence in animals, and difficulties in differentiating...

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PMID: 26925620
DOI: 10.1007/s11274-016-2015-6

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