Article
Change in the balance of excitatory and inhibitory midline fiber crossing as an explanation for the hopping phenotype in EphA4 knockout mice.
The European journal of neuroscience - 1 Oct 2011
Restrepo Carlos E, Margaryan Gayane, Borgius Lotta, Lundfald Line, Sargsyan Davit, Kiehn Ole
Abstract excerpt
Neuronal networks in the spinal cord termed central pattern generators (CPGs) are responsible for the generation of rhythmic movements, such as walking. The axon guidance molecule EphA4 has been suggested to play a role in the configuration of spinal CPG networks in mammals. In EphA4 knockout (EphA4-KO) mice, the normal alternating walking pattern is replaced by a rabbit-like hopping gait, which can be reproduced...
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