Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Adaptive preconditioning in neurological diseases – therapeutic insights from proteostatic perturbations

2 Mar 2016

Abstract excerpt

In neurological disorders, both acute and chronic neural stress can disrupt cellular proteostasis, resulting in the generation of pathological protein. However in most cases, neurons adapt to these proteostatic perturbations by activating a range of cellular protective and repair responses, thus maintaining cell function. These interconnected adaptive mechanisms comprise a 'proteostasis network' and include the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Endoplasmic Reticulum Stress and Disease
Share to Genetics and Neurodevelopmental Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26923166
DOI: 10.1016/j.brainres.2016.02.033

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adaptive preconditioning in neurological diseases – therapeutic insights from proteostatic perturbationsPMID 26923166Read ↗

HormesisSemantic proximity Read ↗

Mitochondrial unfolded protein response (UPR mt ) as novel therapeutic targets for neurological disordersSemantic proximity Read ↗

PERK-opathies: An Endoplasmic Reticulum Stress Mechanism Underlying NeurodegenerationSemantic proximity Read ↗

ER stress inhibits neuronal death by promoting autophagySemantic proximity Read ↗

Endoplasmic Reticulum Stress Coping Mechanisms and Lifespan Regulation in Health and DiseasesSemantic proximity Read ↗

Getting the better of ER stressSemantic proximity Read ↗

Mechanisms of Parkinson’s disease-related proteins in mediating secondary brain damage after cerebral ischemiaSemantic proximity Read ↗

Oxidant Stress and Signal Transduction in the Nervous System with the PI 3-K, Akt, and mTOR CascadeSemantic proximity Read ↗

Autophagy as a Cellular Stress Response Mechanism in the Nervous SystemSemantic proximity Read ↗

ER Stress, CREB, and Memory: A Tangled Emerging Link in DiseaseSemantic proximity Read ↗

ER stress and diseases.Semantic proximity Read ↗

Crosstalk between the UPR and autophagy pathway contributes to handling cellular stress in neurodegenerative diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.